Proteomimetic Peptide Platform

Proteomimetic peptidic constructs are non-natural self-organizing biomimicking systems. They exhibit similar properties to those of proteins, e.g. they have a tendency to fold into specific periodic compact structures with given biomedical function.
 

Proteomimetic peptidic constructs have biological applications where the tailored 3D structure is crucial.
 

They are a novel class of drug scaffolds with tailored molecular shape and surface.
 

We developed a novel and highly efficient technology (a continuous-flow meso-scale reactor) to synthesize such proteomimetic peptides and their derivatives.
 

The complete characterization of the peptidic construct is routinely performed in our state of the art facilities equipped with LD/CD spectrophotometer, NMR spectrometers, custom-made SAXS, WAXS instruments, FF-TEM, SFG spectroscopy, spectrofluorimeter and HPLC.

Proteomimetic peptidic drugs

Proteomimetic peptidic drug candidates can replace the biological role of the non-functional proteins:

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• Novel, functionally designed peptides with a distinct biological activity such as enzyme inhibition, cell membrane penetration, antiviral or antifungal effect.
   

• Conjugation with small molecule for desired pharmacological effect, but different mode of action.
   

The proteomimetic peptide conjugate possesses higher biological activity than those of its building blocks.